Welcome to the Pique-Regi Lab web page. Our research group aims to further our understanding of the human genome by developing computational and statistical methods to analyze large genomic datasets. Our main areas of interest are regulation of gene transcription, chromatin state/accessibility, gene-environment interactions, and genetics of complex traits. Our goal is to characterize the regulatory grammar encoded in the DNA sequence and the impact of genetic variants and environmental changes in determining gene expression levels. We hope that the methods and resources we develop will help to determine the molecular mechanisms leading to variation in complex traits and genome evolution.
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